The college lifestyle is associated with both a high-fat diet and alcohol consumption. While the isolated effects of diet and alcohol consumption on cognition and behavior are well studied, there is little known about the effect of both together. In this study, we created a mouse model of the college lifestyle in order to better understand the potential combined effects of a high-fat diet and alcohol consumption on cognition and behavior. Adult C57BL/6J female mice were exposed to either regular food or high-fat food and daily injections of either saline or ethanol. The Porsolt forced swim test (FST), open field, and novel object recognition test measured depression-like behavior, anxiety-like behavior and locomotion, and memory, respectively.