The Undergraduate Research Journal
The Journal of Young Investigators would like to recognize the best of 2018 in a yearly print edition.
This year we’re giving you the opportunity to get involved, with a cover contest, featured abstracts and a reader’s choice vote! Click below for more information.
Glycation as an endogenous process may alter the structure and biological functions of macromolecules, thus playing an important role in cell growth retardation. This study was conducted to evaluate the levels of glycation precursors, advanced glycation end products, and cell viability under effects of kaempferol, myricetin, and azaleatin in the HGC-27 cell line.
Selective pressure generated by the misuse of antibiotics in medicine and agriculture has resulted in antimicrobial resistance and the subsequent reemergence of several pathogenic bacteria, including Mycobacterium tuberculosis (MT), the etiological agent of tuberculosis (TB) disease. Increased resistance of MT to previously-effective antibiotics is associated with greater incidence rates and burden of TB disease. Novel approaches to infection mitigation must be explored if we are to attenuate the destructive force of this pathogen.
Glycation is the process whereby an enzyme catalyzes the bonding of a sugar molecule to another molecule, which can alter and inhibit cancer cell growth. Dr. Chan-Sik Kim from the Korea Institute of Oriental Medicine concluded in 2017 that preventing the glycation process and removing glycation products from the human body slows down aging.
The Nobel Prize in Medicine and Physiology for 2018 was awarded to Dr. James P. Allison and Dr. Tasuku Honjo for making breakthrough discoveries on strategies for treating cancer by preventing the “ignorance” of tumors by the immune system. Developing cancer cells are normally detected by surveying white blood cells, or T-lymphocytes, that recognize the tumor progenitors as abnormal and target the abnormal cells for destruction. However, as a tumor develops, the cancer cells of the tumor begin to send inhibitory signals to immune cells, causing them to “ignore” the growing tumor until it is virtually invisible to the immune system.
Dr. Longen Zhou is the director of Translational Cancer Research at Johnson & Johnson’s Shanghai headquarters. He has had extensive experience in the area of cancer drug development and working in the industrial sector. Dr. Zhou is very knowledgeable about various topics in health science and medicine. His work involves drugs targeting a variety of different cancers, including but not limited to lung cancer, stomach cancer, and leukemia. He has shared with JYI his insights about working in the field of drug development.
Most spinal cord injuries have an almost immediate and devastating effect on the person’s motor control. These severe impairments result from the interrupted communication between the brain and spinal cord, which deprives the spinal cord below the injury of instructions from the higher-level executive functions in the body. Without the essential sources of direction and excitement from the brain, the parts coordinated below the injury on the spinal cord face severe motor deficits – often complete or partial paralysis.
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