Imagine changing the TV channel just by thinking about it,a mental remote control. What was once a science-fiction fantasy is slowly becoming reality: a team of researchers has demonstrated simple mind control of a screen image. Scientists at the California Institute of Technology and University of California, Los Angeles taught patients to consciously change images on a computer screen through the use of individual brain cells. Their study, published last year in Nature, revealed an apparent ability to control the energy of an individual neuron.
A recent breakthrough at the Gladstone Institute of Cardiovascular Disease at the University of California, San Francisco has the potential to radically change the way doctors treat neurodegenerative diseases. Sheng Ding and his lab were able to successfully convert human skin cells into functional brain cells. Published in Cell Stem Cell, the results of the study could potentially wipe out illnesses like Alzheimer's, Parkinson's, and Huntington's disease.
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The objective of this research was to test the in vitro anti-angiogenic activity of auraptene, a coumarin from citrus peel oil. We tested the ability of auraptene to inhibit in vitro angiogenesis using vascular endothelial growth factor (VEGF)-induced human umbilical endothelial cells (HUVEC) growth stimulation.
The metabolic process of glutamate synthesis in Saccharomyces cerevisiae is governed by a functional model that assumes extramitochondrial localization of glutamate dehydrogenase (GDH). In S. cerevisiae, GDH exists as three isozymes: Gdh1p and Gdh3p, which are NADP-dependent, and Gdh2p, which is NAD-dependent. Previous work has suggested nuclear and/or cytosolic localization, but definitive data are lacking. We attempted to determine the subcellular localization of the three GDH isozymes by enzymatic activity.