Science News

Using CRISPR to Fight ALS

ALS (Amyotrophic Lateral Sclerosis), otherwise known as Lou Gehrig’s disease, is a fatal neurodegenerative disease that involves the loss of motor neurons in the spinal cord, brainstem, and motor cortex. This disease, estimated to be afflicting around 20,000 Americans, leads to progressive muscle weakness throughout the body. Recently, researchers at the University of California in Berkeley used the gene-editing technology, CRISPR-Cas9, to disrupt the mutant SOD1 gene expression in the spinal cord of mice with ALS, effectively extending their lifespan by 25%