Non-Hermitian Wave Mechanics: An Unorthodox Way into Embedded Systems

Non-Hermitian Wave Mechanics: An Unorthodox Way into Embedded Systems

This review outlines an unconventional but timely formulation of quantum dynamics of systems in contact with an environment. This alternative approach to traditional quantum mechanics is generic and is currently gaining attention in a number of fields as, for example, quantum scattering and transport, optical waveguides, devices embedded in an environment, oscillatory classical systems, RLC circuits and other open systems with loss and gain. Here we briefly outline this formulation in which the condition of space-time reflection (PT-symmetry) plays a central role. If PT-symmetry is broken upon parametric change, real energy levels generally turn complex. At the onset of such a symmetry breaking levels coalesce at “Exceptional Points” (EP).

Chronic Traumatic Encephalopathy: Connecting Mechanisms to Diagnosis and Treatment

Chronic traumatic encephalopathy is a progressive neurodegenerative disease that has been linked to the incidence of repetitive mild traumatic brain injuries. As chronic traumatic encephalopathy has no formal diagnosis or treatment, current research is striving to better understand its neuropathology in order to develop effective diagnostic and treatment strategies. This review will outline recent research findings in the understanding of the neuropathological mechanisms of chronic traumatic encephalopathy, and connect these findings to advancements in the diagnosis and treatment of the disease. With the emergence of more sophisticated technology, neuroimaging techniques have shown promise as prospective diagnostic tools.

Application of Neuroscience Principles for Evidence-based Design in Architectural Education

Application of Neuroscience Principles for Evidence-based Design in Architectural Education

We spend approximately 90% of our time within a built environment, whether it is in our homes, offices, schools, city parks, or public spaces. This bears significance, as we are equally shaped by both our genetic makeup as well as our environment, which brings into question of how we experience space, and in turn how these experiences impact our behaviour. To gain a greater understanding of these impacts, neuroscience seeks to root out the principles of biological mechanisms involved in consciousness, spatial navigation and environmental stressors. However, the use of these principles is not discussed extensively within the curriculum of undergraduate or graduate architecture programs in North America.

Therapeutic Potential of Optogenetic Treatment for Individuals with Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic neuroautoimmune condition characterized by neurodegeneration and demyelination throughout the central nervous system. While the pathology of MS is largely unknown, its symptoms are well defined. Current MS therapies such as intravenous corticoid injection, disease modifying treatments (DMTs) and neuro-rehabilitation exist; however most are ineffective as they do not manage symptoms efficeiently, leading to many adverse side effects. Optogenetic stimulation of demyelinated regions may serve as the needed therapy to effectively treat symptoms given the advances achieved in its rapid mechanisms and accurate cell-type-specific delivery strategies. In fact, the hallmark of optogenetic technology is the fast and accurate activation of specific neurons. Current evidence supports optogenetics as a means of controlling or enhancing neural circuitry involved in specific symptoms.