Research

Letter to the Editor: Ultrasound-Assisted Tissue Plasminogen Activator Delivery to Ischemic Strokes

Letter to the Editor: Ultrasound-Assisted Tissue Plasminogen Activator Delivery to Ischemic Strokes

The World Health Organization defines stroke as ‘rapidly developing clinical signs of focal (or global) disturbance of cerebral function, with symptoms lasting 24 h or longer or leading to death, with no apparent cause other than that of vascular origin’(Armstead et al. 2010). Current therapies for ischemic strokes, while effective, have significant hemorrhagic risks to the patient and must be administered within a very narrow timeframe (Frendl et al. 2011; Alexandrov 2010). Therefore, there is a need to investigate novel therapeutic agents as well as improve drug administration techniques to acutely decrease the injury caused to the brain in the event of a stroke, while minimizing the potential for hemorrhages and reperfusion injuries.

Thermal Failure Analysis of Hubs in Outdoor Wireless Mesh Networks

Thermal Failure Analysis of Hubs in Outdoor Wireless Mesh Networks

Netgear® WGT634U 108-megabyte-per-second wireless storage routers mounted within environmental enclosures at outdoor and indoor locations across the Cambridge coverage area serve as signal repeater nodes for the network. Denton, Texas, is a promising site to deploy a wireless network similar to the one in Cambridge. However, the ambient outdoor conditions in Denton differ from those in Cambridge and may exceed the operating envelope of the repeater nodes if not mitigated by well-designed environmental enclosures. By instrumenting asample signal repeater with thermocouples and baking it in a furnace, we determined that the node’s built-in safety shut-off temperature is 130 ± 3 °C and that the temperature at which irreversible damage occurs is in the range of 135 °C to 145 °C.