How Prenatal Exposure to Marijuana Affects Executive Functioning in Young Adults

Every year, 211 million pregnancies occur around the world (WHO, 2007), and during pregnancy, one of the most commonly used drugs is marijuana (“Alcohol, drugs, and babies: Do you need to worry?” 2005). There has been an increase in the amount of pregnant women smoking marijuana to aid their morning sickness. However, marijuana use while […]

If You Give A Mouse A Movie

We have all heard Descartes’ famous quote “cogito ergo sum”—I think, therefore I am. But what does it mean to think? Or perhaps, what is it to think? To answer this question, the Allen Institute for Brain Science has released the Allen Brain Observatory1, a collective, standardized “survey of cellular activity in the mouse visual […]

Dieticians and Nutrition: Are you what you eat?

For many people, “eating healthy” involves more than just avoiding excess fat and adding in plenty of fruits and vegetables. People of different ages, activity levels, and health backgrounds  all have unique nutritional needs. Whether it be a professional athlete, a businessman with diabetes, or a small child with an iron deficiency, dietitians play an […]

Interview with a Lab Manager: Micah Simmons, UAB School of Medicine

Brief intro: Micah Simmons is a lab manager in the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama at Birmingham School of Medicine. He works in the lab of Dr. James Meador-Woodruff, under whom he investigates the molecular mechanisms underlying schizophrenia.   When did you decide you wanted to become a lab […]

Organs Without a Home: The Fascinating World of 3-D Bioprinting

This past February, the Wakeforest Institute of Regenerative Medicine accomplished the most advanced feat of tissue regeneration to date: they created a human ear, and kept it alive attached to the backside of a mouse. The ear, exhibiting human-like vasculature and cartilage development, is a promising beginning to the quest to create customized organs. In […]

A Wear Evaluation of Ultra High Molecular Weight Polyethylene (UHMWPE) against Nanostructured Diamond-Coated Ti-6Al-4V Alloy

doi:10.22186/jyi.31.3.21-26 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References |PDF Abstract Reducing the wear of joint replacements would increase the lifespans of both the replacement and the patient. In this study, the wear of ultra-high molecular weight polyethylene (UHMWPE) against nanostructured diamond (NSD)-coated titanium alloy (Ti-6Al-4V) and uncoated cobalt-chromium alloy (CoCr) hemi-cylinders was compared to determine if the NSD coating results in less […]

AIRE Deficiency Exposes Inefficiencies of Peripheral Tolerance Leading to Variable APECED Phenotypes

doi:10.22186/jyi.31.3.15-20 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References |PDF Abstract Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare, recessive disease caused by mutations in the autoimmune regulator (AIRE) gene. A loss of function at the AIRE locus is widely known to induce autoimmune activation against host tissues due to lack of central tolerance during thymic T cell development. Failure to delete autoreactive T cell clones […]

Exploring Carry-Over Effects to Elucidate Attention Bias Modification’s Mixed Results

doi:10.22186/jyi.31.3.9-14   Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References |PDF Abstract Attention bias modification (ABM) has been shown to decrease self-reported symptom severity for those with social anxiety disorder (SAD). ABM may also decrease attention bias towards threat present in SAD. Currently, the most prominent form of ABM […]

Mutational Analysis of Transcriptional Initiation in Bacteria

doi:10.22186/jyi.31.3.1-8 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References |PDF Abstract Gene expression in bacteria begins with transcription, the process by which the base sequence of DNA is copied into RNA. Promoters contain the DNA structural and chemical information for the initiation of transcription by RNA polymerase. Many bacterial promoters have conserved DNA sequences for this purpose called the -35 region and the […]

Mystery of the Kelmans-Seymour Conjecture Solved After 40 Years

Mathematicians at Georgia Tech have recently announced a proof for graph theory’s Kelmans-Seymour Conjecture. The conjecture, proved by mathematician Xingxing Yu and his team, goes as follows:  ”If a graph is 5-connected and non-planar, then G has a TK5.” Though Yu’s proof itself encompasses over 120 pages and four distinct papers, we can begin to […]

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