Interview With a Reproductive Biologist: A Closer Look at the Life and Work of Dr. Anne Croy

Dr. Anne Croy is a professor in the Department of Biomedical Sciences at Queen’s University. She also holds a Canada Research Chair (Tier 1) in Reproduction, Development, and Sexual Function, which is reflective of the outstanding contributions she has made to the field of reproductive biology. While her current research interests lie with conditions that […]

World’s First CRISPR Clinical Trial

Oncologist Lu You’s research group at Sichuan University injected a patient with CRISPR modified cells on November 15, marking the first time CRISPR gene-editing has been tested in a human. The team delivered modified cells into a patient suffering from aggressive lung cancer as part of their clinical trial at the West China Hospital in Chengdu. […]

Lessons From The Lab Bench

Undeniably, admissions committees prioritize a few select factors in considering applicants for scientific PhD programs. Foremost among them are previous research experience, matching interests with research groups, and undergraduate coursework. After three years of undergraduate research, I have received my fair share of advice on positioning myself for graduate school from colleagues, advisers, and friends. […]

Response of Acacia tortilis to Elephant Browsing in Tarangire National Park, Tanzania: Possible Above-Ground Compensation?

doi: 10.22186/jyi.32.1.1-6 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References | PDF Abstract Large herbivore browsing leads to above-ground compensatory growth for some species of Acacia trees, but strength and variation of the relationship are poorly understood. Acacia tortilis is a keystone species in East African savannas and experiences a wide range of browsing pressure. In this study, terminal bud scale scars were used […]

A Word From the Laureates

Earlier this month, the Royal Swedish Academy of Sciences awarded this year’s Nobel Prize in Physics to David J. Thouless, F. Duncan M. Haldane, and J. Michael Kosterlitz “for theoretical discoveries of topological phase transitions and topological phases of matter.”1 Though currently affiliated with the University of Washington, Brown University, and Princeton University, respectively, the […]

Neurogenesis Unchanged by MTHFR Deficiency in Three-Week-Old Mice

doi: 10.22186/jyi.31.6.39-43 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References | PDF Abstract The primary pathway for removing homocysteine, a potentially neurotoxic molecule, from circulation is via 5-methyltetrahydrofolate. This molecule is converted from folate via an enzyme known as methylenetetrahydrofolate reductase (MTHFR). Polymorphisms in the MTHFR gene have been linked to various pathologies (e.g. neurological disease) and animal models have been developed to study […]

Structural Dynamics of Amyloid-β Aggregation in Alzheimer’s Disease: Computational and Experimental Approaches

  doi: 10.22186/jyi.31.6.44-50 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References | PDF Abstract The nucleation of amyloid-β (Aβ) oligomers, and the fibril formation that follows represents an important pathologic mechanism for Alzheimer’s disease (AD). This has motivated the search for therapeutics that specifically target Aβ, which holds promise to be a cure for AD. However, conventional biophysical approaches like X-ray crystallography and nuclear magnetic […]

When Emotions Run High: How Stereotypes Influence Affective Forecasting

From a football team’s victory to the results of a political election, people frequently try to predict others’ emotional responses to an event — a phenomenon known as affective forecasting in the social sciences. “Doctors might try to gauge the amount of pain people are in when deciding the kinds of drugs to prescribe them, […]

Nanoscopic Designs Win Macroscopic Prize: Chemistry Nobel Prize 2016

The 2016 Nobel Prize in Chemistry has been awarded to Jean-Pierre Sauvage, Fraser Stoddart, and Bernard Feringa for their pioneering work of molecular machines. The award highlights the promise of their intricate designs in a range of applications from medicine to material science. The first breakthrough in the field was made by Sauvage and his […]

Could Regular Physical Activity Protect Us From Cognitive Decline As We Age?

Could exercise be the key to helping prevent dementia as we age? This question was explored by a longitudinal study at UCLA, where researchers studied the impact of physical activity on dementia. Their findings support that there is an inverse relationship between physical activity levels and cognitive decline.    In Physical activity, brain volume, and […]

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