Computer Modeling of Drug Delivery to the Brain

Abstract

Treatment of neurological disease has been impeded by limited drug diffusion across the blood-brain barrier. Convection-enhanced delivery is a drug administration method that can be used to treat diseases of the central nervous system by directly injecting a drug into a patient's brain and allowing the drug to circumvent the blood-brain barrier. However, the transport of a drug in a patient's brain following convection-enhanced delivery is often difficult to predict due to the brain's anisotropic properties, which differ according to direction of measurement. Here, we use the software ANSYS to model a patient's brain using MRI data, and apply rigorous mathematical models to predict the mechanism of drug transport in an individual patient's brain. This report provides a detailed discussion of how ANSYS was used to model convection-enhanced drug delivery to the brain, by describing two simulations. The results can be used to assist physicians in designing patient-specific drug administration using convection-enhanced delivery.

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JYI has a peer-review process through which undergraduate research editors work with faculty mentors at their institutions to determine the validity of journal submissions. This process closely mimics those found in other professional research journals.
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