A molecular treatment paradigm for congenital diaphragmatic hernia

Abstract

Congenital diaphragmatic hernia (CDH) is a life-threatening disease in which the contents of the abdomen encroach upon the heart and lungs of the developing fetus. Despite many advances in managing the condition, it still persists as a major cause of neonatal death in newborns with severe respiratory failure. This review provides a brief context of CDH including its impact, clinical manifestations, and current management & limitations. A possible molecular treatment paradigm is also discussed based on studies linking retinoid signaling to CDH development. This evidence will outline the involvement of retinoid signaling pathways in lung & diaphragm development, the disruption of retinoid signaling resulting in CDH development, and a potential therapeutic modality by the manipulation of the retinoid signaling pathway.
Access full PDF: A molecular treatment paradigm for congenital diaphragmatic hernia
JYI has a peer-review process through which undergraduate research editors work with faculty mentors at their institutions to determine the validity of journal submissions. This process closely mimics those found in other professional research journals.
Follow Us
For all the latest news from JYI, join our Facebook.
For all the latest news from JYI, join our Youtube.
For all the latest news from JYI, join our twitter.
For all the latest news from JYI, join our email list.
Translate