A Word From the Laureates

Earlier this month, the Royal Swedish Academy of Sciences awarded this year’s Nobel Prize in Physics to David J. Thouless, F. Duncan M. Haldane, and J. Michael Kosterlitz “for theoretical discoveries of topological phase transitions and topological phases of matter.”1 Though currently affiliated with the University of Washington, Brown University, and Princeton University, respectively, the […]

Neurogenesis Unchanged by MTHFR Deficiency in Three-Week-Old Mice

doi: 10.22186/jyi.31.6.39-43 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References | PDF Abstract The primary pathway for removing homocysteine, a potentially neurotoxic molecule, from circulation is via 5-methyltetrahydrofolate. This molecule is converted from folate via an enzyme known as methylenetetrahydrofolate reductase (MTHFR). Polymorphisms in the MTHFR gene have been linked to various pathologies (e.g. neurological disease) and animal models have been developed to study […]

Structural Dynamics of Amyloid-β Aggregation in Alzheimer’s Disease: Computational and Experimental Approaches

  doi: 10.22186/jyi.31.6.44-50 Abstract | Introduction | Methods | Results | Discussion | Conclusions |Acknowledgements | References | PDF Abstract The nucleation of amyloid-β (Aβ) oligomers, and the fibril formation that follows represents an important pathologic mechanism for Alzheimer’s disease (AD). This has motivated the search for therapeutics that specifically target Aβ, which holds promise to be a cure for AD. However, conventional biophysical approaches like X-ray crystallography and nuclear magnetic […]

When Emotions Run High: How Stereotypes Influence Affective Forecasting

From a football team’s victory to the results of a political election, people frequently try to predict others’ emotional responses to an event — a phenomenon known as affective forecasting in the social sciences. “Doctors might try to gauge the amount of pain people are in when deciding the kinds of drugs to prescribe them, […]

Nanoscopic Designs Win Macroscopic Prize: Chemistry Nobel Prize 2016

The 2016 Nobel Prize in Chemistry has been awarded to Jean-Pierre Sauvage, Fraser Stoddart, and Bernard Feringa for their pioneering work of molecular machines. The award highlights the promise of their intricate designs in a range of applications from medicine to material science. The first breakthrough in the field was made by Sauvage and his […]

Could Regular Physical Activity Protect Us From Cognitive Decline As We Age?

Could exercise be the key to helping prevent dementia as we age? This question was explored by a longitudinal study at UCLA, where researchers studied the impact of physical activity on dementia. Their findings support that there is an inverse relationship between physical activity levels and cognitive decline.    In Physical activity, brain volume, and […]

Mitochondrial Mishaps Linked to Parkinsons

A recent study from Stanford University suggests that defective mitochondrial clearance may provide the crucial link between genetically and sporadically caused Parkinson’s cases. The researchers have shown that mutations in different genes related to mitochondrial clearance among individuals may cause different ‘types’ of Parkinson’s disease. According to Xinna Wang and her colleagues at Stanford, the Miro […]

Communicating Discoveries: The Career of Science Journalism

In our modern information age, communication of data is rapid, and increasingly innovative and impactful research is being conducted and published at a tremendous rate across the world. Simultaneously, the general public is growing more interested in science, with prominent scientific personalities such as Stephen Hawking being catapulted to fame on a global stage. Science […]

Interview With Dr. Nancy Galambos, A Developmental Psychologist

Dr. Nancy Galambos is a developmental psychologist and professor in the Faculty of Psychology at the University of Alberta. Much of her recent research is centered around the changes that occur in various social and developmental aspects of our lives in adolescence, early adulthood, and onwards (Vargas Lascano, Galambos, Krahn, & Lachman, 2015; Galambos, Fang, […]

ZMapp Trial Gives Hope for Ebola Treatment and Emergency Response

The recent Ebola epidemic killed more than 11,000 people and infected more than 28,000 between 2014 and 20161. The outbreak began in the early spring of 2014, when a new variant of the Ebola virus emerged in Guinea and rapidly spread throughout West Africa2. This crisis prompted an immediate response from the scientific community to […]

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